NFL Network's Ian Rapoport reported that Long could be placed on injured reserve and designated to return.
Rookie James Daniels could be in line to replace the 6-foot-6, 316-pound Long, who has missed 14 games over the two previous seasons due to serious ankle, shoulder, neck and elbow surgeries.
"He played a good game," Bears head coach Matt Nagy said of Daniels. "There were a couple things in there where he got a little bit off balance, but one of his strengths is being able to recover with leverage. A couple other times where he was pulling in the run game and had some thumpers where he was bringing it.
"I thought overall in the pass game, the offensive line did an awesome job protecting. They did a really good job in giving green grass to Mitch [Trubisky]. And specifically [Daniels], I thought for being in there as much as he was, he did well."
Long sustained the injury on Sunday after teammate Dion Sims rolled up on his leg at the end of a play. The 29-year-old Long was helped off the field and later was sporting a walking boot on the foot and using crutches to move around the locker room.
In 2016, Long suffered a severe right ankle injury when fullback Paul Lasike rolled up on his leg. Long had extensive surgery, and then had more surgery for a labrum injury and also for a hand injury.