Wide receiver Malcolm Mitchell, who like Edelman missed the entire 2017 season, was unable to practice during this week's three-day minicamp, multiple media outlets reported.
Mitchell did make it onto the field Thursday for the final day of minicamp but was restricted to conditioning drills, according to NESN.
The news of Edelman's four-game ban for violating the NFL's policy on performance-enhancing substances and Mitchell's inability to practice are the latest blows to New England's wide receiving corps.
Mitchell, a fourth-round selection of New England in the 2016 NFL Draft, had a decent rookie campaign with 32 receptions for 401 yards and four touchdowns.
The 6-foot-1, 200-pounder had an expanded role in the second half of the season, reeling in all of his scoring passes over the final six games.
Mitchell also came up big in the dramatic come-from-behind win over the Atlanta Falcons in Super Bowl LI. He has six receptions for 70 yards as the Patriots rallied from a 25-point second-half deficit before winning 34-28 in overtime.
The Patriots attempted to beef up the position in the offseason with the signings of Jordan Matthews and Cordarrelle Patterson and the addition of Braxton Berrios in the sixth round of the 2018 NFL Draft.