In this case, what happened in that Sept. 11 opener is indicative of the teams meeting in Minnesota for the second time this year.
Both teams underwent significant changes since the Vikings' 29-19 victory.
Minnesota quarterback Sam Bradford completed 27-of-32 passes for 346 yards and three touchdowns in the first meeting, earning NFC Offensive Player of the Week honors. Bradford played only a single half the rest of the season as Case Keenum replaced the injured Bradford and put himself in MVP consideration.
New Orleans jettisoned former Vikings running back Adrian Peterson after a miserable four-game run and thrived with Mark Ingram and rookie Alvin Kamara, becoming one of the league's most dangerous running back duos. The Saints' defense also started to find its way.
"They're a different team than they were Week 1, but so are we," said Minnesota tight end Kyle Rudolph, who scored a touchdown in the first game. "Everyone in the NFL is trying to find their identity early on. They're different from a personnel standpoint and they're also different from a team, like us, who has found their identity."
The teams found their identity but had plenty of personnel changes along the way. The Vikings' defense is healthy, but Keenum has taken hold of the starting quarterback spot and rookie running back Dalvin Cook, who ran for 127 yards and a touchdown in the first meeting, has been out since Week 4 because of a torn ACL.
"There are some similarities in regards to scheme, but I think when you go through a course of an NFL season and you look at the attrition that takes place, there are eight or nine of our starters that are playing in that game that aren't playing in this game, and I'm sure the same exists for Minnesota," New Orleans coach Sean Payton told reporters this week, according to the team's website. "And you begin to take shape as the season progresses to who you become and I think both teams have done that."
In the Saints' case, they altered their offensive identity to rely on Ingram and Kamara. New Orleans ranked fifth in the league in rushing this season as Ingram ran for a career-high 1,124 yards and 12 touchdowns. Kamara led the league with 6.1 yards per carry as the Saints had an NFC-best 4.7 yards per carry as a team.
Peterson had six carries for 18 yards in the first meeting in Minnesota. With the carries being split three ways, Ingram had six carries and Kamara touched the ball 11 times on offense.
"They got a little bit of everything," Vikings defensive end Brian Robison said. "Ingram's more of a downhill runner. Kamara is definitely a guy that can bounce to the outside. He's got speed to hit the edge and they're both really good in the screen game."
The Vikings were second in the league in run defense, allowing 83.6 yards per game. They've held two of their past three opponents to fewer than 46 yards.
Selling out to stop the run isn't a solid strategy either. In last week's win against Carolina, the Saints ran 22 times for 41 yards as the Panthers dared New Orleans quarterback Drew Brees to beat them.
"We've been telling y'all all year, man, don't sleep on Drew," Ingram told the New Orleans Times Picayune. "And if you're going to stack the box and try and stop the run and take us out the game, he's going to hurt you. We've been telling you he's the best quarterback in the league and he's still Drew Brees. He proved that (Sunday)."
Perhaps the biggest change for the Saints has been the development of the defense. After allowing 470 total yards to Minnesota in Week 1, New Orleans gave up 555 to New England the following week. Slowly, communication improved on the back end combined with the play of rookie Marcus Lattimore and Ken Crawley at cornerback.
The Saints were third in the NFL and first in the NFC with 20 interceptions in the regular season. Lattimore led the team with five.
"He's a good player," Vikings Pro Bowl receiver Adam Thielen said of Lattimore. "He's physical. He can run with anybody. He's playing with a lot of confidence right now. He's got great ball skills. He's pretty much got everything you need to be a really good corner in this league."
New Orleans also pressures the passer. Cameron Jordan tied Minnesota's Everson Griffen for fourth in the league with 13 sacks. As a team, the Saints' 42 sacks were tied for seventh in the NFL.
Like Brees, Keenum didn't make mistakes once replacing Bradford. He threw seven interceptions, one fewer than Brees, and the Vikings allowed the seventh-fewest sacks in the league behind a patchwork offensive line.
"He is playing well," Payton told the team's website of Keenum. "You can see him getting the ball to a lot of different guys. These guys, I think, have done a great job on offense. I think they are playing a game really that suits both sides of the ball."
Minnesota should head into Sunday healthy, including the return of rookie center Pat Elflein from a shoulder injury.
New Orleans is battered. Left guard Andrus Peat and defensive tackle Tony McDaniel were placed on injured reserve this week. Receiver Brandon Coleman also missed Wednesday's practice with a neck injury. Tight end Michael Hoomanawanui (back), left tackle Terron Armstead (thigh), defensive end Trey Hendrickson (ankle), defensive tackle Sheldon Rankins (ankle) cornerback P.J. Williams (ankle), Jordan (knee) and defensive tackle David Onyemata (thumb) were limited in the week's first practice.