Gurley rolled up 440 yards and five touchdowns on the ground and added 22 receptions for 309 yards with three scores in the impressive four-game stretch.
The 23-year-old, who finished second in league rushing yards (1,305) behind Kansas City Chiefs rookie Kareem Hunt (1,327), also won the league's monthly award for September. For his part, Hunt was named the league's Offensive Rookie of the Month on Thursday while New Orleans Saints cornerback Marshon Lattimore captured Defensive Rookie of the Month honors.
Pittsburgh Steelers star running back Le'Veon Bell was named the AFC Offensive Player of the Month after rushing for 310 yards and four touchdowns. Bell finished third in league rushing at 1,291 yards this season.
This is Jones' second career selection as Defensive Player of the Month and first with the Cardinals. He was previously named AFC Defensive Player of the Month in November 2013 while with the New England Patriots.
Buffalo Bills free safety Jordan Poyer earned AFC Defensive Player of the Month honors after reeling in three interceptions. His contributions helped the franchise into the playoffs for the first time since 1999.
Chiefs kicker Harrison Butker was the AFC Special Teams Player of the Month after going 15-for-18 on field-goal attempts and a perfect 28-for-28 on extra-point tries.