Gronkowski reeled in nine receptions for a career-high 168 yards in the Patriots' 27-24 win over the Pittsburgh Steelers on Sunday. The 28-year-old has 64 catches for 1,017 yards and seven touchdowns in 12 games this season.
Gronkowski previous earned AFC Offensive Player of the Week honors in Week 14 of the 2011 season.
Los Angeles Rams running back Todd Gurley was named the NFC Offensive Player of the Week after rushing for 152 yards and scoring four total touchdowns in his team's 42-7 rout of the Seattle Seahawks on Sunday.
Kansas City Chiefs cornerback Marcus Peters returned from a one-game suspension to claim AFC Defensive Player of the Week honors. Peters intercepted Philip Rivers on two occasions in Sunday's 30-13 win over the Los Angeles Chargers.
San Francisco 49ers kicker Robbie Gould claimed NFC Special Teams Player of the Week honors after making six field goals, including the game-winning 45-yard kick as time expired in a 25-23 triumph over the Tennessee Titans.