Cutler was tackled on the next-to-last play -- a 1-yard run -- of the first half by Tampa Bay's Ryan Russell. Cutler stayed down for a brief moment and got up slowly.
He did not return for the second half, and the team announced he was under evaluation for a concussion and was ruled out for the rest of the game.
Cutler finished 6 of 12 for 83 yards with one passing touchdown and three interceptions.
He was replaced by Matt Moore.