They played twice last season in the regular season and the playoffs.
They have played six times since 2010 and have met in the playoffs twice.
One key thing will be different when they play on Monday Night Football: Seattle cornerback Richard Sherman will not be on the field and that has a certain Falcons wide receiver upset.
Julio Jones is going to miss going up against Sherman, who suffered a season-ending Achilles injury and has been placed on injured reserve.
"We always have a good time," Jones said. "He'll try to stay on me the whole game a lot of times. Guys start playing me, and then get off, have help and Sherman's not one of those guys. He's comes out and competes every play, just man up."
Last season, Jones had seven catches for 139 yards and one touchdown in a 26-24 loss in Seattle on Oct. 16.
In the playoff meeting, Jones had six catches for 67 yards and a touchdown in the 36-20 victory in the NFC divisional playoff victory.
Jones admits that Seattle has a unique home-field advantage.
"It's very different," Jones said. "The 12th man they have out there, the fans are very loud, but for me it doesn't impact me. It's my job to help others around me to help them make sure it doesn't affect their game because it can be effective because it is that loud there.
"It's one of those things about keeping all 11 guys on the same page at the same time due to the crowd noise. Offensively, if you get off the ball later than normal, obviously ... then you're in trouble already.
"The defensive ends and whatever they've got going on being able to penetrate and get pressure upfield they can create turnovers and put a lot of pressure and stress on the quarterback to make him get the ball out of his hands quickly."
With Sherman out, the Falcons don't know how the Seahawks will try to defend Jones.
"Not knowing how they are health-wise, I would expect Jeremy (Lane) certainly to get some action outside," Falcons head coach Dan Quinn said. "He has the ability to play nickel, and play outside so that kind of versatility is good. Very good competitor, very good speed, good ball skills and he's a good tackler."
The Seattle safeties Earl Thomas (hamstring) and Kam Chancellor (stinger) are also injured.
"As you go through the preparation, the scheme doesn't change," Quinn said. "We'll plan on those players playing."
The Falcons must contain Seattle quarterback Russell Wilson.
"The hardest part to prepare for is some of the unknowns," Quinn said. "With some players, you might say when a quarterback is scrambling to the right he may run it and when he's running to the left he may remain a passer. With him, kind of anything goes in terms of where he may end up."
Jones believe the Falcons must build on their win over Dallas.
"For us, most definitely," Jones said. "Every win is a good win for us and things like that. Yeah, we can build off it because we did a lot of great things in the game, but we've got to continue to keep building.