If you have one of those players on your fantasy team and don't have a replacement ready, check out my Week 10 add/drops article.
Dallas Cowboys quarterback Dak Prescott, New England Patriots star Tom Brady, Detroit Lions quarterback Matthew Stafford and Pittsburgh Steelers star Ben Roethlisberger round out my top five for the week.
Read the descriptions below for more of my favorite Week 10 starts.
Here are my Top 20 options at the position this week.
TOP 20 WEEK 10 RANKINGS BELOW
Seattle Seahawks quarterback Russell Wilson might be playing better than any passer in the NFL. Wilson completed 24-of-45 passes for 297 yards and two scores, while rushing for 77 yards in Week 9. He passed for 452 yards and four scores in Week 8. He now has thrown for multiple scores in four of his last five games. Look for that streak to continue in Week 10 as Wilson lines up against the Arizona Cardinals on Thursday Night Football. The Cardinals are tied for allowing the fifth-most fantasy points per game to opposing quarterbacks.
Detroit Lions gunslinger Matthew Stafford is my No. 4 option for Week 10 with a matchup against the Cleveland Browns. The Browns have allowed the seventh-most fantasy points per game and are tied for allowing the third-most touchdowns to opposing quarterbacks. Stafford completed a season-best 78.8 percent of his passes for 361 yards and two touchdowns in Week 9. He has thrown for at least 300 yards in three consecutive games. Start him with confidence for the rest of the season.
Pittsburgh Steelers quarterback Ben Roethlisberger passed for a season-high 317 yards in Week 8's win against the Lions and had a week off to recover. I expect him to finish off Week 10 as a top 5 option. This week he gets the Indianapolis Colts, a defense that has allowed the most passing yards and ninth-most fantasy points per game to opposing passers.
Atlanta Falcons quarterback Matt Ryan isn't putting up an impressive response to his 2016 MVP campaign, but he should be a solid start in Week 10. He is my No. 7 option for the week with a matchup against the Dallas Cowboys, a defense allowing the 12th-most fantasy points per game to opposing passers. I expect the Falcons to air it out in this home contest.
Eli Manning and the New York Giants travel this weekend to face the San Francisco 49ers, a defense allowing the third-most fantasy points per game and passing touchdowns to opposing quarterbacks. Manning is a low-end QB1 in deeper leagues and my No. 13 option this week.
The Tampa Bay Buccaneers will be without starter Jameis Winston for multiple games, opening the door for veteran quarterback Ryan Fitzpatrick. While Fitzpatrick isn't ever an ideal play, he could find success in Week 10 against a New York Jets defense that is allowing the most passing touchdowns and eighth-most fantasy points per game to opposing quarterbacks.