The 51 points allowed by the Giants represented the most they have given up in a home game since Sept. 19, 1999, when Washington scored 50.
The Rams (6-2) scored on five of their first six possessions in the first half, with two of their scoring drives set up by turnovers. The first such score came when Giants quarterback Eli Manning was sacked on third-and-9 by defensive tackle Aaron Donald, who forced the ball out and to teammate Connor Barwin.
Four plays later, Goff connected with tight end Tyler Higbee on an 8-yard touchdown. Higbee also became the ninth opposing tight end to catch a touchdown pass against the Giants this season.
The Giants (1-7) managed to even the score on what was their best possession of the first half, a 14-play drive that split the rushing and passing attempts evenly. Manning found receiver Tavarres King on the 5-yard score, but it was all downhill from there.
The Giants would get a 50-yard field goal from Aldrick Rosas, who would later miss a 45-yard attempt just before the half, but otherwise, it was all Rams in the second quarter.
The Rams took the lead for good with 14:55 left in the second quarter on Greg Zuerlein's first of two field goals in the quarter, a 27-yarder.
Goff then provided some spark with two consecutive deep touchdown passes. The first, set up by Giants running back Wayne Gallman's fumble, was a 52-yarder to receiver Robert Woods that came on third-and-33. The second was a 67-yard strike to receiver Sammy Watkins.
Zuerlein would later record a 46-yard field goal to close out the half, and a 47-yarder for the Rams' final points of the afternoon.
The Rams, who finished the game having scored on nine of their 12 possessions, kept piling it on, starting with their opening drive of the second half with a 1-yard touchdown run by Todd Gurley to make it 34-10.
On their next possession, Gurley made it 41-10 when he caught a 44-yard pass from Goff to set up first-and-goal from the Giants' 1-yard line. Two plays later, Goff connected with a wide-open Woods for his second touchdown of the game, a 4-yarder over the middle.
Cory Littleton then blocked a Brad Wing punt deep in Giants territory to set the Rams up on the Giants' 18-yard line.
Three plays later, Gurley scored on a 4-yard touchdown, his second score of the third quarter, before Rams head coach Sean McVay pulled Goff (14 of 22 for 311 yards and four touchdowns, 146.8 rating) in favor of backup Sean Mannion.
The Giants managed a fourth-quarter touchdown on a 10-yard pass from Manning to tight end Evan Engram to make it 48-17.
NOTES: Giants QB Eli Manning became the seventh player in NFL history to pass for 50,000 yards, joining Peyton Manning, Brett Favre, Tom Brady, Dan Marino, John Elway and Drew Brees. ... Giants LB Keenan Robinson suffered a quad injury in the first quarter and did not return. ...The Rams surpassed the 30-point mark for the fifth time this season. They scored 30 or more points just five times from 2014-16. ... The last time the Giants allowed 40 or more points in a game was in a 52-49 loss at New Orleans on Nov. 1, 2015.