The contest will be the second straight missed by Freeman, who reportedly is navigating his way through the final stages of the concussion protocol. The two-time Pro Bowl selection is not practicing, but has been running sprints on the side of the field.
"He's doing well," Atlanta coach Dan Quinn said, per ESPN. "He's going to visit with the independent part of the protocol come up here soon. He won't play in this ball game. He won't practice today. He's back to full-speed running. But it's soon that he'll be back participating full speed in practice. But you won't see him suited up for this weekend."
Running back Tevin Coleman is expected to draw the start on Saturday with Terron Ward and rookie fifth-round draft pick Brian Hill also seeing significant action.
Freeman signed to a five-year, $41.25 million contract extension in the offseason after helping the Falcons in their run to the Super Bowl. The 25-year-old started all 16 regular-season games and led the team with 1,079 rushing yards to go with 462 receiving yards on 54 receptions. Freeman had 13 total touchdowns.
Freeman has amassed 2,383 rushing yards in his three seasons since being selected with a fourth-round draft pick out of Florida State in 2014.
Freeman rolled up 3,175 yards from scrimmage over the past two seasons, second in the league to teammate Julio Jones. He has rushed for 11 touchdowns in each of the past two seasons and has 29 total TDs in 47 regular-season games.