Arians, 64, had a portion of his kidney removed in February. He was hospitalized in November due to chest pains. He was also taken to the hospital in August due to stomach pain.
The veteran coach revealed his latest health issue in his new book, titled: The Quarterback Whisperer. The book was released Tuesday.
Arians said he was out at dinner in December with his wife when his doctor called. An ultrasound later showed a spot on his kidney.
He coached the entire season until having it removed, but he says he feels "great" now.
"My energy has returned. I'm told I'm cancer-free again. I'm ready for at least one more season of NFL football-maybe more," Arians wrote in his book, according to the Cardinals' team website.
Arians had a bout with prostate cancer in 2007 and has cancerous cells removed from his nose in 2013.
The Quarterback Whisperer was co-authored by Lars Anderson and is 352 pages. Arians earned the nickname for his expert honing of NFL gunslingers, including: Peyton Manning, Ben Roethlisberger, Andrew Luck and now Carson Palmer.
"Proud and excited for my book release today! Show me where you are reading #TheQuarterbackWhisperer for a chance to win a signed copy," Arians tweeted Tuesday.
Arians owns a 41-22-1 record in more than four seasons as an NFL head coach. He posted a 9-3 record in 2012, stepping in as an interim coach for the Indianapolis Colts. Arians' Cardinals posted a 13-3 record in 2015, before slipping to 7-8-1 in 2016.
"I now realize more than ever nothing is guaranteed in life," Arians wrote, according to AZCardinals.com. "Every day needs to enjoyed and celebrated to the fullest. Roses need to be smelled, sunsets savored, time with family cherished. Moving forward, I want to be a beacon of hope for others struggling with cancer. My fight is their fight. I'm not coaching for myself in 2017; I'm coaching for everyone who's dealing with cancer. This is my charge."
The coach also had issues with migraines when he coached at Temple University, according to ESPN.
Arians owns a 1-2 career record in the playoffs. He began his professional coaching career in 1989 as running backs coach for the Kansas City Chiefs.