According to multiple reports, 28 people were injured in the shooting at the Power Ultra Lounge on Saturday morning. None of the injuries are considered life-threatening.
McFadden, who played collegiately at the University of Arkansas, addressed the situation on Twitter.
"The other night, while at home, I received a call from my nephew that there was a shooting at the club (Power Ultra Lounge) where he and some of my relatives were," the 29-year-old McFadden said in a Twitter message on Monday night.
"He told me that he got shot, many other people were shot and that some of my relatives were among those shot. Out of concern for all of the people affected by this horrible tragedy, I went down to the scene to check on my relatives and to offer any help I could."
McFadden's mother told KARK TV that the family members injured were Marvell Harris, 23; Wallace Muhammad, 35; and Marquette Muhammad, 16.
McFadden, 29, was born in Little Rock and is a former Heisman finalist with the Razorbacks.