Beane will get a second interview with the Bills for their general manager vacancy, a source told ESPN's Adam Schefter.
Beane, 39, was the first of three candidates to interview with Bills owners Terry and Kim Pegula at their home in Boca Raton, Fla.
Beane is familiar with new Bills head coach Sean McDermott, who spent six seasons with the Panthers as the defensive coordinator.
Beane has been in the NFL for 19 years, all with the Panthers. He also worked as director of football operations and was named assistant general manager in June 2015. He served as interim GM in 2012 before the Panthers hired current general manager Dave Gettleman.