The 31-year-old Peterson has been slowed with knee and groin injuries for the second straight week after he returned from a torn meniscus in Week 15 against the Indianapolis Colts on Dec. 18. The 2012 NFL MVP has not practiced since the Colts game, and will finish the season with 37 carries for 72 yards and no touchdowns in three games.
Peterson suffered a torn meniscus against the Green Bay Packers in Week 2 on Sept. 18. He underwent surgery four days later.
The Vikings, who have an option on Peterson for the 2017 that includes a $6 million roster bonus on the third day of the league year, likely will request a restructured contract for next season.
Peterson turns 32 in March and is set to earn an $11.75 million base salary in 2017. He could earn a $250,000 workout bonus in addition to the roster bonus.
Peterson led the NFL in rushing in 2015 with 1,485 yards, along with 11 touchdowns. He has 11,747 career rushing yards with 97 touchdowns in 10 seasons -- 16th on the NFL's all-time list. He is 565 yards behind Jim Brown for 10th place.
Wide receiver Stefon Diggs (hip), guard Alex Boone (lower back) and receiver Laquon Treadwell (ankle) were listed on Friday's injury report as doubtful for the game. Receiver Charles Johnson (knee) was listed as questionable.
The Bears did not rule out any players, but linebacker Leonard Floyd (concussion) was listed as doubtful.