Levy was listed as questionable on Wednesday's injury report but will miss his 10th straight game with a knee injury. He will continue to be replaced in the lineup by a combination of Josh Bynes and Antwione Williams.
Diggs, nursing an ailing knee, did not participate in Tuesday's or Wednesday's practice and was listed as questionable. He leads the team in receptions (67) and receiving yards (747). Cordarrelle Patterson will start in his place.
Lions running back Justin Forsett, quarterback Jake Rudock, tackle Cornelius Lucas, safety Don Carey, offensive lineman Joe Dahl and defensive tackle Khyri Thornton were also inactive.
Vikings cornerback Marcus Sherels, defensive tackle Sharrif Floyd, quarterback Taylor Heinicke, tackle Rashod Hill and defensive end Stephen Weatherly were the other inactives.