Making his first start of the season for the Jets, Smith left Sunday's game against the Baltimore Ravens after sustaining a knee injury while being sacked in the second quarter at MetLife Stadium.
Smith, who was 4 of 8 for 95 yards and a touchdown, was taken down by Matthew Judon for an 8-yard loss on third-and-6 play. He was seen pointing to his knee upon reaching the sideline and soon headed for the locker room. Smith returned in street clothes in the second half and was ruled out for the contest.
Enter Ryan Fitzpatrick, who was benched for Smith after throwing two touchdowns and 10 interceptions four consecutive losses. He finished 9 of 14 for 120 yards and a touchdown Sunday in New York's 24-16 win.
The 31-year-old veteran could be placed on injured reserve, multiple media outlets reported. ESPN reported he will miss at least eight weeks.
Hoyer sustained the injury in the second quarter Thursday in the Bears' 26-10 loss to the Green Bay Packers when he was hit by linebackers Clay Matthews and Julius Peppers on a third-down pass attempt.
Norman banged the side of his head tumbling over receiver Marvin Jones Jr., who made a diving 52-yard reception on a deep throw from Matthew Stafford despite Norman committing pass interference on the play. After being evaluated on the field, Norman immediately headed to the locker room with assistance from the Redskins' medical staff.
Earlier in the game, Lions cornerback Darius Slay injured a hamstring and was declared out for the remainder of their game.
Reid was hit by Chargers linebacker Denzel Perryman as the teammates converged to make a tackle.
Chargers cornerback Craig Mager sustained a concussion in the third quarter during the game. Mager, who was hurt making a tackle, was wobbly leaving the field. He was taken to the locker room for additional evaluation, and the concussion diagnosis was made.
Later in the period, San Francisco starting outside linebacker Aaron Lynch (shoulder) and backup cornerback Rashard Robinson (knee) sustained injuries.
Miller's injury occurred early in the third quarter while he attempted to rush Raiders quarterback Derek Carr. Miller fell to the ground and had to be helped off the field by two members of the team's medical staff.
Brooks was injured without making contact when he attempted a tackle against running back Jerick McKinnon. Rookie Jalen Mills replaced Brooks.
--New Orleans Saints starting left guard Senio Kelemete walked off the field with trainers due to a stinger.
Just a few moments earlier, New Orleans starting left tackle Terron Armstead left the game due to a lower leg injury. Armstead was helped off the field and taken by cart to the locker room for further examinations.
Saints wide receiver Jake Lampman left the field after covering a kickoff with a right knee injury.