The NFL is monitoring the situation after consecutive nights of civil unrest in the city.
The police shooting of 43-year-old Keith Lamont Scott on Tuesday sparked outrage and violent protests that were entering their third day of Thursday.
"We are in contact with government officials, the Charlotte-Mecklenburg Police Department and the NFL," Panthers president Danny Morrison said in a statement. "We are continuing to monitor events as we prepare for Sunday's home game."
One of the concerns is that the city's security personnel are being stretched thin due to the situation, and a byproduct of the attention given riots is there might not be enough available police officers to handle security at Bank of America Stadium on Sunday.
One of the possibilities is the NFL choosing to move the game to a different location. As of mid-day Thursday, that possibility wasn't being pursued.
One large-sized stadium 140 miles away is 62,980-seat Kenan Memorial Stadium on the campus of North Carolina. But the Tar Heels play on Saturday against Pittsburgh and security would be a major concern.
Charlotte is about four hours away from Atlanta and the Falcons are on the road this Sunday, meaning the Georgia Dome could conceivably be available. The next event scheduled for the venue is a Beyonce concert on Monday.
Just last season, the Baltimore Orioles postponed two home games against the Chicago White Sox in late April due to protests in the wake of the death of Freddie Gray, who died in police custody on April 12, 2015.
Baltimore and Chicago played the final game of their three-game series in an empty Camden Yards on April 27.
Charlotte leaders are still attempting to restore order and the governor has called in the National Guard. A curfew also could be set in place as soon as Thursday night.
The violence in Charlotte erupted after Scott was killed on Tuesday.
Scott, who is black, was shot by a black police officer. He reportedly was sitting in a vehicle when police approached him at an apartment complex. Scott exited his vehicle and was told to drop his weapon. Police say he didn't comply with repeated requests.
Scott's family claims he was reading a book in the vehicle.
Police have refused to release video of Scott's shooting until an investigation is complete.
The situation has prompted heightened fear and heavy emotions throughout Charlotte.
Former NBA player Muggsy Bogues, a longtime Charlotte fixture after playing 9 1/2 seasons in the city, was distressed over what is occurring. Bogues played college hoops at Wake Forest in Winston-Salem, about an hour away from Charlotte.
"This is not the city that I came to in 1988. I was really saddened to see the violence," Bogues told CNN. "People are angry. I understand that. People want transparency. They're tired of our young men being gunned down. ... You also have to look at the police side -- they have to do their job."
Panthers star quarterback Cam Newton said people need to be held accountable.
"When you get a person that does some unjust things or killing an innocent person; killing fathers; killing people who have actual families," Newton told reporters on Wednesday. "That's real. Like, I have a son. How would it be and the daughter that I'm responsible for?
"How would it be if one day they come home and there's no more daddy? And it's not like OK, well you can get a (monetary) settlement. Money doesn't matter in that sense. You need people to be held accountable. And that's all."
NASCAR is based in Charlotte and closed its office for normal business on Thursday. Some windows on the ground floor of its building were broken during Wednesday night's protest.
The adjacent NASCAR Hall of Fame was open on Thursday.
The shooting of Scott comes in the wake of the ongoing social-injustice protest being conducted by NFL quarterback Colin Kaepernick. The San Francisco 49ers' player has been kneeling during the national anthem and players from other teams have joined in.
Kaepernick has been vocal about police shootings, including a recent incident in which 40-year-old Terence Crutcher was killed by police in Tulsa, Okla.
"They shot and killed a man and walked around like it wasn't a human being," Kaepernick told reporters. "People are getting killed and not even being treated as human beings. No one went and checked on him. No one tried to resuscitate him. Nothing.
"They walked around, wanted to go about their business and made up lies to cover up their murder that they just committed. That's not right and they should be in prison for that."
Kaepernick said he has receiving death threats since going public with his stance.