The Miami Heat star was welcomed with screams, high-fives and applause as he walked through the school.
"First of all, I am so excited to be back in this city, be back in this state," Wade said when addressing the students.
"I just want to come here today, and hopefully, for a moment, for a second, bring a little bit of this," Wade said in video captured by Twitter user @rain_valladares. "Bring a little excitement, bring a little joy."
"What you guys have been going through and ... how resilient you guys have been -- I've been amazed from afar. I just wanted to come and say I'm inspired by all of you. As someone out here in the public eye, I am proud to say I'm from this state."
The 36-year-old NBA veteran spent the first 13 seasons of his decorated professional basketball tenure with the Heat, before stints with the Chicago Bulls and Cleveland Cavaliers. He was traded back to the Heat on Feb. 8.
One of the 17 casualties of the shooting -- 17-year-old student Joaquin Oliver -- was buried with Wade's No. 3 Heat jersey. Wade teared up when he was notified of that gesture last month before writing Oliver's name on his shoes for a game against the Philadelphia 76ers on Feb. 27 in Miami. The 12-time All-Star went on to make the game-winning shot against the Sixers that night at AmericanAirlines Arena.
Wade also met up with Oliver's family on Saturday after the Heat beat the Detroit Pistons in Miami. He handed them a pair of customized basketball shoes, which included the Stoneman Douglas Eagles' logo and Oliver's name. He also gave the Oliver family one of his jerseys.
"I just had a great conversation with some of the students at Stoneman Douglas High School about some important/impactful things that they have planned," Wade tweeted. "I'm looking forward to being more involved in the change that they WILL create. #MSDStrong."
"Our conversation about bridging the gap between the students from Parkland, Florida and Chicago was really impressive," Wade added. "These young adults GET IT. They understand the power of their voices for the ones that often go unheard!"
I just had a great conversation with some of the students at Stoneman Douglas High School about some important/impactful things that they have planned. I’m looking forward to being more involved in the change that they WILL create. #MSDStrong 💪🏾💪🏾💪🏾— DWade (@DwyaneWade) March 7, 2018
Wade's 16-year-old son, Zaire, attends American Heritage School in Plantation, Fla., which is located about 20 miles south of Stoneman Douglas.