The Cavs officially announced James and Irving as out and the third member of the Big 3 -- Kevin Love -- as questionable for the game at AmericanAirlines Arena,
The team apparently decided to give the star players rest before the playoffs over continuing the fight for the No. 1 seed in the Eastern Conference.
James played 47 minutes before fouling out in Sunday night's stunning 28-point collapse, the Cavs losing 126-125 in overtime to the Atlanta Hawks. Irving played 45 minutes and Love 42.
The Cavaliers listed a projected starting lineup of Deron Williams at point guard, J.R. Smith at shooting guard, Channing Frye at center, Richard Jefferson at power forward and Iman Shumpert at small forward.