After Aldridge had an occurrence of the heart arrhythmia in Oklahoma City on Thursday, the Spurs' medical staff led a process that included multiple tests and examinations as well as consultation with numerous experts in the field.
"LaMarcus has been cleared to play," Spurs coach Gregg Popovich said before Wednesday night's home game against the Portland Trail Blazers. "So we're obviously thrilled about that, but more importantly thrilled that the doctors feel that he's fine in a sense that we're not putting him in danger or anything like that. So that's the most important part."
The 6-foot-11, 260-pound Aldridge is averaging 17.3 points, 7.4 rebounds and 1.1 blocked shots in 58 games this season. He signed with the Spurs in 2015 after spending his first nine seasons in Portland.
Aldridge will be available with no restrictions against the Trail Blazers, the Spurs announced.
Aldridge, 31, has a history of heart-related issues.
At the end of his rookie season with the Trail Blazers in April 2007, Aldridge was diagnosed with Wolff-Parkinson-White syndrome, which is an abnormality that can cause a rapid heartbeat.
Aldridge underwent a procedure to fix the problem and missed the final nine games of the season. Four years later, he underwent the same procedure and missed time at the start of the 2011-12 season when there was a recurrence of his condition.
"We are thankful that LaMarcus will be able to rejoin the team," Spurs general manager RC Buford said in a statement. "All of us have been impressed with the professionalism and grace he has shown in dealing with this difficult situation."
Popovich also announced that point guard Tony Parker (back) is questionable for Wednesday's game, and his backup, Dejounte Murray, is out with a groin injury.