Love already has been ruled out for Tuesday night's road game against the Minnesota Timberwolves. He underwent an MRI exam Sunday after experiencing pain in his knee in the previous night's game against Denver.
Cavaliers coach Tyronn Lue expressed consternation over Love's condition at Monday's practice.
"Always concerned when guys are going down," Lue said. "And we're already limited as it is. Definitely concerned, but gotta see how he feels. Just, get evaluated (Tuesday) and see how he feels."
The 28-year-old Love is averaging 20.0 points, 11.1 rebounds and 1.9 assists for the Cavaliers (37-16), who have won five of their last six and hold a 2 1/2-game lead over Boston in the Eastern Conference.
Love missed a pair of games earlier in the season due to back soreness but Lue did not say whether the ailments could be related and was unsure if Love would be able to play in this weekend's All-Star Game.
Channing Frye already has been announced as the starter for Love against the Timberwolves. Cleveland hosts Indiana on Wednesday in its final game before the All-Star break.