Now they will have to do it without their leading scorer, All-Star guard DeMar DeRozan, who will miss at least the next two games with a sprained right ankle.
DeRozan was injured in the loss to the Phoenix Suns on Sunday when he stepped on another player's foot. He continued to play but it was worse on Monday.
"When it rains, it pours sometimes," said DeRozan who is averaging 27.9 points per game. "Once you get through that part of it, it always comes out to be worth it. That's how I always look at it. I think I'm just an optimistic type of guy and that's how I look at everything."
The Raptors have lost three in a row for the first time this season and face the Spurs, who defeated the Brooklyn Nets Monday night 112-86 despite being without star forward Kawhi Leonard, who had a sore hand.
Leonard, an MVP candidate, is expected to return.