Tanaka replaces Toronto Blue Jays pitcher Marcus Stroman, who will miss the game with shoulder soreness. Woodruff replaces teammate Josh Hader, who has been bothered by a sore back and will not pitch Tuesday night in Cleveland.
Tanaka is 5-5 with a 3.86 ERA and 90 strikeouts in 18 starts this season. He was named to the All-Star Game in 2014 but did not pitch because of an elbow injury.
Woodruff is 10-3 with a 3.67 ERA across 18 starts. He has emerged as a breakout candidate for the Brewers and has 126 strikeouts in 108 innings.
Vazquez was an All-Star last season. He has 19 saves and a 2.19 ERA in 32 games this year.
The 2019 MLB All-Star Game is Tuesday at 7:30 p.m. EDT. The game will air on Fox.