Devers lined a ground ball to Guerrero, who speared the ball before falling down. Guerrero recovered and moved into a sitting position before throwing the ball to first.
First baseman Rowdy Tellez caught the ball on the bounce for the 5-3 putout.
The out served as one of Toronto's few highlights in Thursday's 8-2 loss to the Red Sox. Toronto allowed seven runs in the final four innings for their second straight defeat.
The Blue Jays are 20-30 this season. Toronto is 12 1 /2 games back of the New York Yankees for first place in the AL East Division.
Guerrero has been a bright spot for the Blue Jays since joining the big-league club on April 26. He has five home runs and 11 RBIs in 83 at-bats.