The bomb came in the top of the third inning during the 9-7 win on Thursday at Wrigley Field in Chicago. Phillies star Bryce Harper got the scoring started with an RBI single in the first inning. The Phillies got another run after a wild pitch from Jon Lester.
Philadelphia added two more runs in the third inning. Rhys Hoskins brought in Jean Segura with a sacrifice fly before Realmuto hit a solo home run for a 4-0 advantage.
The 456-foot shot had an exit velocity of 111 mph and a launch angle of 28 degrees, according to Statcast.
Andrew McCutchen had a ground out RBI in the fourth frame. Sergura plated McCutchen with a two-run home run in the same frame, pushing the lead to 7-0.
Odubel Herrera pushed the Phillies' lead to 8-3 with a ground out RBI in the fifth inning, before Kyle Schwarber and Rizzo homered in the seventh inning. Schwarber hit a two-run shot and Rizzo smacked a solo homer to get the Cubs within two runs of the Phillies.
McCutchen plated the Phillies' ninth run in the eighth inning with an RBI double.
Tyler Chatwood attempted to spark a rally in the ninth inning. The Cubs pinch hitter plated Rizzo with an RBI double in the final inning, but Chicago could not even the score.
Aaron Nola moved to 5-0 on the season, allowing four hits and three runs in 5.1 innings for the Phillies. Realmuto was 1-for-4 with an RBI, a run scored, a walk and two strikeouts in the victory. Harper was also 1-for-4 for the Phillies.