Major League Baseball announced that the 8:15 p.m. game has been moved to 7:45 p.m. Wednesday. Fans holding tickets for Tuesday's game can use those same tickets to attend the make-up game.
Wednesday's first game, which is a separate admission, will start as scheduled at 1:15 p.m.
Right-handed pitcher Homer Bailey was set to take the mound for the Royals on Tuesday, while the Cardinals were expected to start right-hander Michael Wacha.
Wacha and Bailey presumably will pitch in one of Wednesday's games.
The Cardinals and Royals each have lost four of their last five games entering the two-game series at Busch Stadium in St. Louis.