Those 54 hitless at-bats set a new Major League Baseball record for position players, according to the Elias Sports Bureau.
The two-run single came against Red Sox pitcher Rick Porcello, who Davis now has 11 lifetime hits against.
Davis' last hit before Saturday's two-out, line-drive single was a double against White Sox righty James Shields last September 14.
Last season, Davis hit .168 with 16 home runs for Baltimore.
The 33-year-old inked a seven-year $161 million dollar contract during the 2015-16 offseason to stay with the Orioles.