The Nationals ace fired a 96 mph fastball past Cano on his first offering of the exchange. He then lofted in an 86.7 mph changeup for a ball. Scherzer went with another changeup with his third offering, but left it over the middle of the plate.
Cano smacked the poorly-placed pitch to dead center, clearing the outfield fence for a 406-foot solo home run. The swat had an exit velocity of 106 mph and a launch angle of 22 degrees, according to Statcast.
The Mets slugger grounded out in his next at-bat. He was 1-for-2 with an RBI and a run scored through four innings. Scherzer allowed just two hits and one run, while tossing seven strikeouts and allowing a walk through four innings.
Cano joined the Mets in December as part of a seven-player trade with the Seattle Mariners. The eight-time All-Star hit a career-low 10 home runs and had a .303 batting average in 80 games last season in Seattle.