The game lasted seven hours and 20 minutes, officially becoming the longest contest in MLB postseason history.
Max Muncy produced the fourth World Series walk-off homer in Dodgers history, pushing the ball just over the left center field wall off Boston's Nathan Eovaldi. It was the Dodgers' first walk-off win in the World Series since Kirk Gibson's historic home run in 1988.
Leading off the 18th inning, Muncy had an early 3-0 count. Eovaldi, who threw 97 pitches in relief across six innings, battled back to a 3-2 count. On the seventh pitch in the at-bat, Muncy connected on the series-saving home run.
Dodgers outfielder Joc Pederson opened the scoring with a solo home run to right field in the bottom of the third inning off Boston starting pitcher Rick Porcello.
Porcello threw 4 2/3 innings and only allowed three hits, with his lone earned run allowed being Pederson's solo shot.
Dodgers starting pitcher Walker Buehler dominated across seven innings, giving up only two hits and silencing the Red Sox's bats throughout the night. He added seven strikeouts and didn't surrender a walk.
Boston finally broke its offensive dry spell in the top of the eighth inning. Reliever Kenley Jansen replaced Buehler and gave up a solo homer to Red Sox outfielder Jackie Bradley Jr. to tie the game at 1-1.
Later in the 13th inning, Brock Holt scored on a throwing error by Dodgers pitcher Scott Alexander to give the Red Sox a 2-1 advantage.
Needing one run to stay afloat, Muncy scored on a throwing error by second baseman Ian Kinsler to keep the Dodgers' hopes alive and force a 14th inning.
Muncy's solo shot was the deciding run in the 18th inning.
The series remains in Los Angeles on Saturday with the Red Sox still holding a 2-1 lead.