Jones saved his heroics for the bottom of the 11th inning in the 3-2 win at Oriole Park at Camden Yards.
The five-time All-Star stepped in to face Twins right-handed receiver Fernando Rodney as the first batter in the extra frame for the Orioles. Jones only needed to see one pitch.
He turned Rodney's initial offering -- a 92 mph two-seam fastball -- into a long ball to left field for the Orioles' first win of the 2018 campaign.
Baltimore held onto a 2-0 lead through seven innings. Caleb Joseph's seventh inning triple brought in those two scores. But Robbie Grossman tied the game for the Twins when he hit a two RBI single to center in the ninth inning.
Both teams played a scoreless 10th inning before Jones stepped up for the deciding swat.
Jones went 1-for-5 with two strikeouts in the win. Catcher Caleb Joseph went 1-for-3 with two RBI for the Orioles.
"Adam, he's just been a guy. One of the first guys I spent some time with when I got here was Adam. So, obviously, I've got a little special affinity for the things he brings. I understand him and the rough edges we all have, but he's very consistent. Especially with his baseball. You know what you're getting every night. That's a lot of games to not ever walk up the runway and not feel like he wasn't ready to play."
The Orioles host the Twins again at 7:05 p.m. Saturday in Baltimore.
"That's a fitting way to end Opening Day," Jones said on MASN's Orioles broadcast after the win.