Both Sale and Severino earned All-Star nods for their respective clubs, with Sale getting the start for the American League. Severino did not pitch in the game.
A six-time All-Star, Sale (11-4, 2.75 ERA) allowed three hits and struck out two in two scoreless innings in his second consecutive start in the Midsummer Classic on Tuesday.
It was the first career All-Star selection for Severino (5-4, 3.54 ERA), who capped his first half with a 10-strikeout performance against the Milwaukee Brewers last Saturday after allowing a three-run homer to Domingo Santana in the first inning.
Severino said he would have pitched the 11th inning for the AL, but former Yankee Robinson Cano's go-ahead home run in the 10th robbed him of that opportunity -- and that's OK by him.
"I wanted to win," Severino said after the All-Star game. "Maybe (I'll get to pitch) next time."
After dropping 18 of 25 games entering the All-Star break, New York (45-42) let another game slip away Friday as Boston (51-39) won 5-4 on a ninth-inning walk-off walk with Andrew Benintendi at the plate against closer Aroldis Chapman.
"It's a credit to our guys of not maybe losing focus inside some at-bats," Red Sox manager John Farrell said after his team trailed 4-3 entering the ninth. "We battled, we fought back. Just a good finish."
Sale has been accustomed to good finishes this season. His 178 strikeouts at the break led the majors and were the most by a major leaguer before the All-Star Game since Curt Schilling struck out 186 batters over 19 starts in 2002.
Like Schilling, Sale has also proven to be a difficult opponent for the Yankees. Sale is 4-2 with a 1.31 ERA in 11 career outings (eight starts) against the Bronx Bombers.
On April 27, Sale took a hard-luck loss after allowing three runs (two earned) on eight hits and no walks while striking out 10 in an eight-inning loss to the Yankees in Boston.
Sale is 6-1 with a 2.34 ERA at Fenway this season.
Severino's career numbers against the Red Sox (1-3, 4.07 ERA) or at Fenway (1-1, 4.26 ERA) are not eye-popping, but he spun a gem in his only start against the Red Sox in Boston this year.
On April 26, Severino tossed seven scoreless, three-hit innings with two walks and six strikeouts in a 3-1 victory.
Dustin Pedroia is 3-for-7 with a home run and five RBIs lifetime against Severino, Mitch Moreland is 1-for-4 with two RBIs and Benintendi is 2-for-5 with an RBI.