Mitch Moreland's hit proved to be the timeliest.
Moreland smacked a go-ahead two-run double in Boston's three-run seventh and the Red Sox broke the game open with a five-run eighth in an 11-3 rout of Detroit on Saturday night at Fenway Park.
"All night long we did a very good job with long at-bats, staying within the strike zone, really being relentless at the plate which is what we try to instill, try to take pride in," Boston manager John Farrell said.
Moreland and Andrew Benintendi each had three RBIs for the Red Sox. Sale (8-2) allowed three runs, nine hits and no walks while striking out seven in seven innings.
It was Sale's first victory in six head-to-head matchups with Verlander on the mound for the Tigers.
"That's a tough team over there. I've seen quite a bit of them," Sale said, referring to his days facing the Tigers in the American League Central with the Chicago White Sox. "They've given me some fits over the years. ... Teams like that, it's nice to kind of get over the hump."
Nicholas Castellanos, Miguel Cabrera and Mikie Mahtook each drove in a run for the Tigers, who have dropped three in a row and four of their last five.
Verlander, who left Sunday's start against the Chicago White Sox with a groin injury, gave up three runs, five hits and four walks with three strikeouts in a five-inning no-decision.
"I was cognizant of (my groin) but (I) made it through about as good as I could have hoped for," Verlander said. "I was just ... aware of it and not trying to overdo anything."
Warwick Saupold (1-1) took the loss after giving up three runs in an inning of relief.
Rutledge made it 6-3 after Moreland's decisive hit in the seventh with an RBI single.
Boston put the game out of reach with a five-run eighth.
Mahtook's single to shallow center field with one out in the sixth inning tied the score 3-3.
Pedroia opened the scoring with a sacrifice fly to right field after Rutledge and Leon singled and Mookie Betts walked to load the bases with nobody out in the Red Sox's third.
After Verlander struck out Bogaerts for the second out, Moreland drove an RBI single to right to make it 2-0.
Castellanos ripped an RBI double just past the reach of the lunging Rutledge at third base to put the Tigers on the board with one out in the fifth. Cabrera tied it on a soft 4-3 groundout in the next at-bat.
Verlander loaded the bases again in the fifth and Benintendi gave Boston a 3-2 lead with a sacrifice fly to center for the inning's second out. The former American League MVP and Cy Young Award winner needed 108 pitches to get through five innings.
NOTES: Boston RHP Carson Smith (Tommy John recovery) threw 25 pitches off a mound, but still has no timetable to return. LHP Eduardo Rodriguez (right knee subluxation) threw long toss out to 130-140 feet on flat ground. ... Monday is the 10-year anniversary of Tigers RHP Justin Verlander's first no-hitter, versus Milwaukee. "I wanted to celebrate with everybody, but (catcher Ivan "Pudge" Rodriguez) just had me. I couldn't get away," he recalled to MLB.com. ... ALS advocate Pete Frates gave personal belongings to the Baseball Hall of Fame on Saturday. Frates, a former Boston College baseball player diagnosed with the disease at age 27 in 2012, inspired the ALS Ice Bucket Challenge that has raised more than $250 million. "Lou Gehrig is the first (person) that comes to mind, but ... Pete might become the face of the disease," Red Sox manager John Farrell said. ... Tigers LHP Daniel Norris (2-4, 4.48 ERA) opposes Red Sox LHP Drew Pomeranz (6-3, 4.02) on Sunday.