Buehrle, who spent 12 seasons with the club, guided the White Sox to the 2005 World Series title. He also tossed a no-hitter against the Texas Rangers in 2007 and a perfect game versus the Tampa Bay Rays two years later.
"A standout on the field and a standup teammate in the clubhouse, it is our honor to retire Mark Buehrle's No. 56 and to welcome him into the legendary class of all-time White Sox greats," Chicago chairman Jerry Reinsdorf said. "Mark Buehrle is one of the most accomplished pitchers in franchise history."
Buehrle will be the 12th player to have his number retired by the club. The ceremony will take place prior to Chicago's game against the Oakland Athletics.
Buehrle owned a 161-119 record with a 3.83 ERA for the White Sox from 2000-2011.He posted a 214-160 mark with a 3.81 ERA with three teams in 16 seasons.