Charlotte fired four-time NBA All-Star Mark Price after two-plus seasons, the school announced Thursday.
Price, who signed a five-year deal worth $500,000 per season in 2015, posted a 30-42 overall mark and a 16-20 record in Conference USA during his time with the 49ers.
Assistant coach Houston Fancher will guide the 49ers (3-6) on an interim basis, the school announced.
"We appreciate all that coach Price has done for our program," athletic director Judy Rose said in a statement. "His background and knowledge were assets to our young players and we appreciate him sharing his talents with our team. This was a difficult decision, especially as we make plans to open conference play, but we do feel it is in the best interest of our basketball program."