The move ends Gore's streak of 126 consecutive games played, which was the longest active stretch among any NFL running back, wide receiver or tight end.
Gore had also started 122 straight games, the longest run for any NFL running back since Eddie George's string of 130 in a row from 1996-2004.
The 35-year-old Gore resides fourth all-time on the NFL's rushing list with 14,748 yards in 14 NFL seasons, trailing only Pro Football Hall of Famers Emmitt Smith, Walter Payton and Barry Sanders. He resides 521 yards behind Sanders for third place.
Gore, who sustained a sprained foot in the second quarter of Sunday's 41-17 setback to the Minnesota Vikings, hasn't showed his hand on whether he'll re-sign with the Dolphins or another NFL team.
"After the season, I'll see. But I still feel good and (I'm) having fun," Gore said last week.
A five-time Pro Bowl selection, Gore has rushed for a team-leading 722 yards while reeling in 12 receptions for 124 yards and a touchdown for the Dolphins (7-7), who host the Jacksonville Jaguars (4-10) on Sunday (1 p.m. ET).
Gore returned to the city where he was born and starred at the collegiate level when he signed a one-year contract with the Dolphins in March.
Kenyan Drake has a team-leading four rushing touchdowns to go along with 469 yards on 103 attempts.
Fellow running back Kalen Ballage, who highlighted a 123-yard performance versus the Vikings with a 75-yard touchdown run, and Brandon Bolden likely will receive additional playing time as well.