The Bucs will have a full complement of running backs on the active roster against the Panthers after promoting Russell Hansbrough from the practice squad.
However, Tampa Bay starting running back Doug Martin suffered a hamstring strain in the first quarter of the Week 2 game at Arizona and has not returned to the field. Martin was listed as doubtful for Monday night.
Sims, 26, suffered a knee injury against the Denver Broncos on Oct. 2.
Sims played in four games for Tampa Bay this season, starting two. He rushed 41 times for 116 yards, with one touchdown, while catching 14 passes for 112 yards and one score.
Last season, Sims rushed for 529 yards and caught 51 passes for 561 yards and four touchdowns in 16 games.
The 5-foot-9, 195-pound Hansbrough joined Tampa Bay as a college free agent out of Missouri this offseason. He was with the Buccaneers through the preseason and spent time on the team's practice squad.
Hansbrough, 22, played in 48 games at Missouri, rushing for 2,344 yards and 15 touchdowns.