Wilkerson has been limited in practice this week due to ankle and toe injuries, according to the team's final injury report released Wednesday. His toe injury was a nail removal.
Jets linebackers David Harris and Bruce Carter also are listed as questionable due to shoulder injuries. Linebacker Jordan Jenkins (calf) and cornerback Darryl Roberts (foot) are listed as doubtful. Quarterback Bryce Petty remains out with the right shoulder injury he suffered in the preseason.
Bills left tackle Cordy Glenn has been ruled out with an ankle injury. Glenn hurt the same ankle that kept him out for the entire preseason during the 13-7 loss to the Baltimore Ravens last Sunday. Cyrus Kouandjio will get the start against the Jets.
Safety Colt Anderson (foot) also has been ruled out for the Bills.
Buffalo wide receiver Sammy Watkins is listed as questionable but the third-year star said he plans to be in the lineup. Watkins, who has been plagued by discomfort in his left foot, was limited in practice on Wednesday.
Other players listed as questionable for the Bills are defensive tackle Jerel Worthy (knee), tight end Jim Dray (ankle), tight end Charles Clay (kee), cornerback Kevon Seymour (hamstring) and quarterback Cardale Jones (right shoulder).