"He went for an MRI on his ankle," Cubs manager Joe Maddon said after the game. "You saw him jog off the field when I pulled him. ... I don't even want to create conjecture. Let's just see what happens, let's look at the tests."
Bryant, the 2015 National League Rookie of the Year, apparently rolled the ankle while running the bases in the third inning. Bryant was replaced by Javier Baez in the fifth.
"I was watching him coming from second to third," Maddon said. "I watched him hit the inside of the bag, but I did not see any hitch in his giddy-up. I saw a really good turn and I focused somewhere else at that point."
Bryant was batting .289 with four homers, 15 RBIs and 17 runs scored after the series finale with the Brewers.