Deputy prosecuting attorney Kerry Glen said Wednesday she plans to file documents to drop the case after Reyes' wife also refused to return to Maui.
"The complaining witness, Mr. Reyes' wife, is what we call an uncooperative witness," Glen said. "At this point, I have no other avenue for prosecution."
Reyes, 32, was scheduled to go to trial on Monday. He pleaded not guilty to abusing a family or household member.
Reyes' playing status with the Rockies remains in limbo because he could still face a suspension by Major League Baseball. He was placed on paid administrative leave on Feb. 23 under MLB's domestic violence policy pending completion of the criminal proceedings.
Reyes was at the Wailea Four Seasons resort on Maui when hotel security officials placed a 911 call on Oct. 31. According to a transcript of the 911 call, the hotel security staff reported that Reyes' wife, Katherine Ramirez, had suffered injuries to her face, neck and leg.
Reyes was arrested on Halloween night after being accused of grabbing his wife by the throat and shoving her into a sliding glass door.
MLB and the Players' Association agreed on the domestic violence policy last August.
"My expectation is, once that process plays out, we'll be in position to act quickly," MLB commissioner Rob Manfred said earlier this month.
Reyes is scheduled to make $22 million this season and is the Rockies' highest-paid player. He is owed $56 million through 2017.
Reyes, a four-time All-Star, was acquired in the trade on July 28 that sent longtime Rockies shortstop Troy Tulowitzki to the Toronto Blue Jays. Reyes hit only .259 with three home runs and 19 RBIs in 47 games in Colorado last season.
Reyes batted .274 with seven home runs and 53 RBIs in 2015 for the Blue Jays and the Rockies. He is a career .290 hitter with 118 homers and 621 RBIs.