Djokovic set a record with his sixth ATP World Tour Masters 1000 title of the year and improved his record to 27-4 against Top 10 opponents in 2015.
"The best players in the world are playing. It's very intense, you play basically every day," Djokovic said of the Masters 1000 series. "Very demanding physically, mentally. And to be able to come out on top again, it's truly amazing.
"I'm enjoying and cherishing this year and every moment that I spend on the court. It's much easier to play when you know you've won so many matches. It gives you confidence, it gives you freedom to play well. I'm experiencing the best time of my career and I'm trying to enjoy it."
Djokovic broke Murray's serve in the third game of the match, but the Englishman broke right back to even the first set. Djokovic then took a 3-1 lead that he extended to 5-2 and closed out the set in 42 minutes.
The two again traded service breaks in the second set, and Murray had an opening leading 3-2 and at 0-30 on Djokovic's serve, but the Croatian reeled off nine consecutive points to hold his serve and break Murray for a 4-3 lead and claimed the title three games later.
Djokovic has now won 22 consecutive matches and has won 10 of his past 11 meetings against Murray. He has now won the Paris event four times.
Murray was the first British finalist at the BNP Paribas Masters since Tim Henman won the event in 2003.
"It was a pleasure to play here this week in the beautiful new stadium," Murray said during the trophy ceremony. "Congratulations to Novak. It's been a great year for him.
"It's been a great week for me - first time past the quarterfinals. That's progress and I hope to be back next year."