The Heat had a three-point lead cut down to one twice during the game's waning stages, but Wade found Hassan Whiteside for pick-and-roll baskets on both ensuing possessions to help Miami pull out an important victory.
Whiteside did his part as well, corralling a career-best 25 rebounds and adding 18 points and four blocks. Goran Dragic also made a big contribution for the Heat, scoring 21 points for a second straight game to go along with six assists.
The Lakers fell for the 13th time in their last 14 road outings despite seven players scoring in double figures. Ed Davis finished with 14 points and 12 rebounds, Wayne Ellington also had 14 points, Jordan Hill posted 13 with 10 boards and Carlos Boozer ended with 13 points.