Miami was without All-Star guard Dwyane Wade for the sixth straight game. Wade has been sidelined with a strained right hamstring and is questionable to play in the All-Star game next Sunday.
Bosh scored Miami's first seven points of the fourth quarter and put the game away at 4:18 with a deep triple. He then put the finishing touches on his terrific night with an elbow jumper on the next possession to push the lead to 98-84.
Carmelo Anthony paced the Knicks with 26 points before departing in the second half to get his left knee examined. Amar'e Stoudemire added 14 off the bench as the Knicks fell for the fourth straight game.
Anthony shot out of the gate like a cannon, sinking all four of his 3-point tries and pouring in 14 points in the first quarter. The Knicks led by as many as 14 and took a 32-23 lead into the second.
Cole's 3-pointer at 5:20 of the second had Miami back within three, and New York's once-comfortable lead was down to 56-52 at halftime.
Trailing by two late in the third quarter, Danny Granger hit a pair of free throws and Chalmers canned a 3 to make put the hosts up 77-74. They led the rest of the way.
The six assists are the most that Bosh has recorded in a Heat uniform ... Knicks F/C Andrea Bargnani made his season debut and scored four points in 14 minutes ... The Heat have won five straight in the series ... Cole had a game- high eight assists.