Jamal Crawford added 19 points off the bench for the Clippers, who improved to 6-2 on a nine-game homestand. Matt Barnes scored 18 points, Chris Paul tallied 17 points and 13 assists and J.J. Redick contributed 16 points.
Dallas coach Rick Carlisle was ejected after getting two technical fouls in the third quarter.
The game was officiated by two referees after 63-year-old Joe Crawford left in the second quarter with a right knee injury.
The Clippers led 32-24 following Crawford's layup in the opening seconds of the second quarter. However, Dallas scored the next eight points to tie things up.
With the score tied 45-45 late in the second quarter, Los Angeles went on an 11-3 run to make it 56-48 at the half.
The Clippers then started the third stanza on a 14-2 surge. Griffin tallied six points during the burst, including a jumper with 8:39 remaining to make it 70-50.
Los Angeles led 88-72 after three and cruised to victory in the fourth.
The Clippers went 3-1 against the Mavericks in 2013-14 ... DeAndre Jordan had 13 points and 15 rebounds for Los Angeles, which shot 52.3 percent from the field and went 13-of-31 from beyond the arc ... Chandler Parsons ended with 12 points for Dallas.