The Spurs opened a three-game homestand with a 99-87 victory over the Brooklyn Nets on Saturday and were led by Tony Parker's 22 points and seven assists. Both Kawhi Leonard and Danny Green scored 21 points for the Spurs, who shot 51.9 percent and improved to 4-1 at home.
For the first time this season, three Spurs had 20 or more points. They posted a 54-34 advantage in the paint.
"We were kind of fresh for this game and I thought we were really focused," said Parker. "We played great defense and kept our lead the whole game."
Tim Duncan scored a season-low seven points and had 10 rebounds. He has recorded 10 boards in three straight games.
San Antonio is first in opponents' scoring at 91.3 ppg.
Spurs guard Cory Joseph (ankle) is doubtful Wednesday and forward Matt Bonner (illness) is questionable versus the Pacers.
San Antonio, which has won seven of its last eight games to improve to 9-4, will also host Sacramento on Friday.
Indiana has won five of its last seven games since a 1-6 start and handed the Dallas Mavericks a 111-100 loss on Monday thanks to Donald Sloan's 29 points on 10-of-14 shooting. Luis Scola ended with a double-double of 14 points and 11 rebounds for the Pacers.
"I knew going in that there would be more shots coming towards my way," said Sloan. "Also we played a bit faster. So there would be a lot of shots going up a bit quicker. I kind of took that kind of full stride going into the game. I knew getting a few more shots this game I had to knock them down."
Solomon Hill and Rodney Stuckey scored 12 points apiece, while Damjan Rudez (11), Chris Copeland (11) and Ian Mahinmi (10) rounded out the double-digit scorers in the win. Hill is averaging 13.6 points in 11 games this month.
Pacers center Roy Hibbert missed the game with a sprained left ankle and is doubtful for Wednesday. Hibbert is averaging 13.1 points and 7.8 rebounds.
Indiana is fourth in opponents' scoring at 94.4 ppg, but is averaging only 92.4 points on offense. The Pacers lost their first three road games, but have prevailed in each of the past three away from home to even their mark at 3-3.
The Pacers are 4-1 when leading after three quarters and 1-4 when opposing teams scored 100 or more points.
San Antonio and Indiana split a pair of games last season with each team winning on the road. The Spurs, though, have dominated the Pacers lately to the tune of a 16-3 mark in the past 19 encounters.
Indiana snapped an 11-game losing streak in the Alamo City with a 111-100 victory last Dec. 7, but is 2-14 in the last 16 visits there.