Joe Flacco threw a pair of touchdown passes to Owen Daniels, Justin Tucker kicked four field goals and Baltimore forced three turnovers in putting the focus back on football if but for a few hours.
The blowout win came three days after disturbing new video footage was released showing franchise running back Ray Rice punching his now-wife in an Atlantic City casino elevator.
Rice had been already been suspended two games for the incident, but the graphic nature of the video led to his outright release and an indefinite suspension by the NFL.
The controversy will continue to dominate the headlines in the coming weeks, both in the way the situation was handled by the league and Rice's playing future, but the Ravens (1-1) did not appear fazed by the frenzy.
Flacco played mistake-free and threw 71 of his 166 yards to Steve Smith, Sr., while Bernard Pierce and Justin Forsett combined for 152 rushing yards to help Baltimore rebound from a season-opening loss to the Bengals.
Pittsburgh (1-1) recorded six first downs in the second half -- four coming in its final drive with the outcome already decided.
Ben Roethlisberger completed just 22-of-37 passes for 217 yards with an interception and was held without a touchdown pass for the first time since the final game of the 2011 season.
Le'Veon Bell gained 107 yards from scrimmage after amassing 197 in a Week 1 win over the Browns.