Tuukka Rask stopped 21 shots, as Boston clipped Phoenix, 2-1, at TD Garden.
Zdeno Chara and Jarome Iginla tallied for the Bruins, who extended their season-high win streak to seven games.
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Claude Julien also recorded the 300th win as Boston head coach.
Lauri Korpikoski provided the lone goal and Mike Smith made 18 saves for the Coyotes, who finished 2-2 on their four-game road swing.
[SportsNetwork.com]