The Penguins became the first team in the NHL to reach 30 victories.
Pittsburgh scored the game's first four goals, getting one each from Jokinen and Kunitz in the first period and two more from Jokinen and Sidney Crosby in the second.
The Rangers cut their deficit in half in the third on a pair of goals from Mats Zuccarello, but Kunitz scored on a slap shot with 7:06 to play to end any thoughts of a New York comeback.
Both Kunitz and Crosby have 23 goals this season and Pittsburgh's total of 136 leads the Eastern Conference.
The Penguins improved their home record to 18-3-0.