SAN FRANCISCO, Sept. 22 (UPI) -- Andrew Luck ran for a touchdown and the Indianapolis defense yielded just 254 total yards Sunday in the Colts' 27-7 victory over San Francisco.
Luck, who starred at nearby Stanford where he played under 49ers Coach Jim Harbaugh, completed 18-of-27 passes for 164 yards and didn't commit a turnover for Indianapolis (2-1).
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Ahmad Bradshaw led the Colts' ground game, picking up 95 yards with a touchdown on 19 carries, while newly acquired Trent Richardson added a touchdown.
On defense, Indianapolis held San Francisco quarterback Colin Kaepernick to just 150 yards on 13-of-27 passing, forcing an interception and a lost fumble.
Frank Gore ran for 82 yards on 11 attempts for the 49ers (1-2).