The Orioles scored three more times in the first inning. Two runs came on Wieters' RBI double and the other on a wild pitch by Brandon Mauer (2-4) who took the loss.
Baltimore added a pair in the top of the sixth, which Seattle answered with two runs in their half of the frame.
Jason Hammel (4-1) picked up the win for the Orioles after allowing two runs on seven hits in five innings. Hammel pitched to three batters in the sixth and served up a home run pitch to Michael Morse.