The Lakers have lost all three of their regular season games after going 0-8 in the exhibition campaign. The Clippers have started the year at 2-0.
Butler's long-range shot lifted the Clippers into a 52-47 halftime lead and they then opened the second half on a 10-4 run. Their lead grew to 15 at the start of the fourth quarter and it did not fall below 10 the rest of the way.
The Clippers beat the Lakers for the fifth time in 20 games.
Kobe Bryant, who suggested to media members that they were overreacting to the Lakers' first two losses of the year, put up 40 points in the losing effort. He was 14-of-23 from the field and perfect in 10 free-throw tries.